This retrospective study was carried out in the internal medicine and gastroenterology outpatient clinics of a tertiary hospital in Istanbul from 01 January 2010 to 01 July 2012. In this study we aimed to investigate MPV levels in patients with CD or UC. Recent studies reported different results about the correlation between MPV and other inflammatory markers in inflammatory bowel diseases. In case of an inflammation, platelets undergo structural modification and secrete some cytokins which result with a decrease in mean platelet volume. Therefore, a non-invasive biomarker for IBD has been a focus in IBD researches. There is no any gold standard test or examination for to determine the type, disease activity and prognosis of inflammatory bowel diseases. Platelets are mainly involved in homeostasis but recent studies have shown that they also have an important role in inflammatory response.

Increased acute phase reactants like C-reactive protein (CRP), fibrinogen and ferritin are important parameters indicating the activity of disease as well as increased erythrocyte sedimentation rate (ESR), thrombocytosis and leukocytosis. However, pathologic evaluation of the disease activity may not be correlated with clinical and endoscopic findings.Ĭlinical activities of both diseases are assessed by specific activity indices. The clear distinction between the two diseases is established by only histopathologic examination. The assessment of IBD is based on a clinical symptoms, physical examination, laboratory tests, radiology and endoscopy with histology. Genetic, environmental and immunological factors are associated with the pathogenesis of both cases. Ulcerative colitis (UC) and Crohn’s disease(CD) are inflammatory bowel diseases (IBD) that affect different regions of gastrointestinal tract. Mean platelet volume, Ulcerative colitis, Crohn’s disease Introduction A significant correlation was found between MPV and CRP only in active CD patients (r=-0,527 p=0,009).Ĭonclusion: Although MPV was found to be associated with chronic inflammatory conditions, we did not show any association between inflammatory bowel disease.

CRP levels were higher in patients with CD (p<0.001). Results: Groups were similar in terms of age, sex and MPV levels (p=0.09, 0.08, 0.459, respectively). The correlation between MPV and CRP was assessed. Groups were compared regarding MPV and CRP levels. The study group consisted of 100 patients with IBD (UC: 50 and CD:50) and the control group included 100 healthy subjects. Methods: A total of 200 subjects were enrolled.

In this study we aimed to investigate MPV in patients with IBD. Mean platelet volume (MPV) and inflammatory markers are affected in chronic inflammatory diseases. Background: Crohn’s disease (CD) and ulcerative colitis (UC) are main inflammatory bowel diseases (IBD) which show progression with remissions and exacerbations.

Low mpv blood test